Common cause of bacteremia in pediatric cancer patients with fever and vetropeni in Shafa Hospital, Ahvaz; 2009-2010

Ahmad Shamsizadeh, Zohreh Karami, Roya Nikfar

Abstract


Introduction: Neutropenia can cause life-threatening infections in patients with cancer and is Gram-negative staphylococci are the most common pathogens. The pattern of infection of bacteria has changed significantly over the past decades. We aimed to access the bacterial and fungal causing infection in patients with fever of malignancy. Methods: It was cross-sectional study which has done on 70 patients aged 0-15 years with fever, neutropenia and malignancy; those were referred to Shafa hospital during 2009-2010. From all patients has requested to collect two samples of blood culture and in case if it was necessary one sample of fungal culture. Data has entered and analyzed by SPSS software (version 21). Statistically significant difference was indicated at significance level (P-Value) of 0.05. Results: Finding of this study has shown that number of  female and male were 28  and 42 respectively and the mean age of patients was 8.02 ± 4.18 years and average Absolute neutrophil count (ANC) was 7.377 ± 47/398 Lμ. Neutropenia was the most common underlying disease causing Acute lymphoblastic leukemia (ALL) (50%). Out of all patients, 3.24% of them had bacteremia and none of them had fonogmy. The most common gram-negative organisms was Pesedomona Anrojroza (35.83%) due to bacteremia, followed by Acinetobacter, Escherichia coli, Klebsiella and Atro bacteria attitude. All gram-positive strains of S. Coe types were negative. Gram-negative microorganisms have had highest susceptibility to imipenem, amikacin; ceftazidime Jentmaysyn .gram negatives compared to only 8.13% were susceptible. Conclusions: The model organism isolated from patients with fever and neutropenia in cancer is not the same in different parts of the world and Still the most common gram negative Ayzvah emergence of the region are therefore therapeutic direction for empirical therapy should be focused on Gram-negative. Ceftazidime is not a good choice for initial treatment.

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References


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